18. Update after 2 weeks in the daily trial

I had my weekly blood/labs/doctor visit today at the Fred Hutchinson in Seattle for the clinical trial I am on.

I had my weekly blood/labs/doctor visit today at the Fred Hutchinson in Seattle for the clinical trial I am on.

A Partial Update On What The ABT-199 Has Done In Two Weeks Have Been On This Drug Daily

Day one of taking the daily ABT-199 pill versus 2 weeks later of a daily pill

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WBC 11,870 ~ 5,670  (Normal is anywhere between 4.3 and 10.0)

(Also significant as my WBC went from 8,100 to 11,870 in one week after the 7 day wait from the first pill to taking the daily pill) 

Lymphocytes (ALC) 7.84 ~ 2.38  (Anything over 4.8 is considered high)

Some very good results in only 2 weeks of taking a daily pill!! YAY!!!!!

The first week was 50 mg a day, the 2nd week was 150 mg a day. And tomorrow, the beginning of week 3 will have me at 1,200 mg a day.

I asked the trial coordinators why they were picking on me as the biggest known dose they know of is 800 mg a day. They smiled and said yes we are, and because partially Abbott (who is putting on the trial), said I was the youngest and healthiest, without other underlying health problems, who is currently on the trial with the 6Q, 11Q and 13Q deletions. And with an un-mutated status showing CD5, CD20, CD38, CD19, CD45.

Did I hear BINGO out there?

I asked about the ones on the trial with the 17p, but only got an answer that I was over 10 years younger and much healthier than those. (Ha, calling someone with CLL/SLL healthy?). So I guess I get to be the lucky lab rat?!?

My new breakfast of champions.

Two 300 mg pills of Allopurinol (with a low fat breakfast, usually a bowl of oatmeal),


Then twelve 100 mg pills of the ABT-199 all within 30 minutes of eating the low fat 

breakfast,  (plus it takes just a bout a full bottle of water to down the 12 pills!)

Needless to say I am FULL!! 


Bonaparte......................

17. Boring Updates!

I had my follow up visit at the Fred Hutchinson Cancer Clinic in Seattle for the clinical trial I am for the ABT-199, for the Leukemia I am batteling.

The doc's PA actually said I am a boring patient!
I guess boring is good. As numbers continue to be stable and have gotten a smidgen better.

So now its time to triple the dosage I am on from 50 mg a day to 150 mg a day. They are confident that this will trigger a little better response.

Then next week the plan is to bump it right up to 1,200 mg a day. Again, I will the only person to get this big of a dosage to date, so it might get interesting!

Also got a little good news that they will now allow me to go to a the local clinic 15 minutes from my home for blood work/labs tomorrow and Wednesday instead of having to make the 2 to 3 hour round trip trek to downtown Seattle in rush hour traffic unless I need to see my medical staff, and the local clinic will fax results and Fed EX test sample to them from there. Gonna also save me a little sanity on the freeway during the local storms we have been getting lately!

So now its time to see how this lab rat does on bigger doses of this experimental drug. The trial coordinators, PA, and I were joking that I might show up next week with a 3rd arm, or be able to pick up radio signals from mars! LOL!

Never Ever Give Up!